Fig. 3

MCUR1 facilitates epithelial-mesenchymal transition and HCC metastasis. a Representative immunohistochemical staining images of E-cadherin and Vimentin in the orthotopic transplantation nude mice model of HCC metastasis. b Histological analyses of intrahepatic and lung metastatic nodules from HCC metastasis nude mice model by hematoxylin and eosin (H&E) staining. Images showing representative H&E staining of liver and lung tissue samples from the different experimental groups (n = 5 /group). c The number of intrahepatic and lung metastasis nodules was quantified in H.E. sections. d Representative immunohistochemical staining images and IHC score of MCUR1 in HCC without metastasis (n = 74) and HCC with metastasis (n = 63). e MCUR1 expression positively correlated with tumor progression of HCC patients. Data shown are the mean ± SD from three independent experiments. * P < 0.05; ** P < 0.01