Fig. 6

Hsa_circ_0068871 can promote tumour formation in xenografted nude mice. a Representative images of nude mice injected with EJ cells (five mice per group). b Representative images of xenograft tumours in nude mice. c The growth curves of xenografts (**p < 0.01, ***p < 0.001). d Extract protein from tumours and measuring protein expression of FGFR3 using Western blot. e Immunohistochemistry (IHC) staining of FGFR3 in xenografts. Scale bar = 100 μm for 10 × and 100 μm for 20 ×. f The schematic diagram shows the mechanism through which hsa_circ_0068871 regulates FGFR3 expression and activates STAT3 targeting miR-181a-5p