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Table 2 Univariate and Multivariate Analyses of Factors Associated With survival and recurrence

From: TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4

  Overall survival Cumulative recurrence
Multivariate Analysis Multivariate Analysis
Variable Univariate P HR 95%CI P* Univariate P HR 95%CI P
Age, year (≥60 vs. <60) 0.230    NA 0.286    NA
Gender (Men vs. Women) 0.741    NA 0.798    NA
Anatomic site (Acra vs. Trunk vs. Other) 0.858    NA 0.887    NA
Histologic type (Superfical spreading vs. Nodular vs. Acral vs. Lentigo maligna) 0.089    NA 0.054    NA
Ulceration (Present vs. Absent) 0.284    NA 0.249    NA
Breslow depth (mm) (≤2 vs. > 2) 0.014 1.839 1.347–2.916 0.037 0.024 1.526 1.135–2.527 0.046
Clark level (I-III vs. IV-V) 0.023    NS 0.031    NS
Lymph nodes metastasis (Yes vs. No) 0.015    NS 0.015    NS
Distant metastasis (Yes vs. No) 0.002    NS 0.003    NS
Clinical stage (Yes vs. No) 0.004 3.853 2.325–6.518 0.001 < 0.001 4.104 2.395–6.718 < 0.001
TRIM44 staining (Low vs. High) 0.010 1.297 1.040–2.215 0.019 0.005 1.230 1.012–2.010 0.004
  1. Note: OS overall survival, DFS disease free survival, NS not significant, NA not adopt
  2. *, p < 0.05 was regarded as statistically significant, p value was calculated using Cox proportional hazards regression