Table 2 Univariate and Multivariate Analyses of Factors Associated With survival and recurrence
From: TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4
Overall survival | Cumulative recurrence | |||||||
|---|---|---|---|---|---|---|---|---|
Multivariate Analysis | Multivariate Analysis | |||||||
Variable | Univariate P | HR | 95%CI | P* | Univariate P | HR | 95%CI | P |
Age, year (≥60 vs. <60) | 0.230 | NA | 0.286 | NA | ||||
Gender (Men vs. Women) | 0.741 | NA | 0.798 | NA | ||||
Anatomic site (Acra vs. Trunk vs. Other) | 0.858 | NA | 0.887 | NA | ||||
Histologic type (Superfical spreading vs. Nodular vs. Acral vs. Lentigo maligna) | 0.089 | NA | 0.054 | NA | ||||
Ulceration (Present vs. Absent) | 0.284 | NA | 0.249 | NA | ||||
Breslow depth (mm) (≤2 vs. > 2) | 0.014 | 1.839 | 1.347–2.916 | 0.037 | 0.024 | 1.526 | 1.135–2.527 | 0.046 |
Clark level (I-III vs. IV-V) | 0.023 | NS | 0.031 | NS | ||||
Lymph nodes metastasis (Yes vs. No) | 0.015 | NS | 0.015 | NS | ||||
Distant metastasis (Yes vs. No) | 0.002 | NS | 0.003 | NS | ||||
Clinical stage (Yes vs. No) | 0.004 | 3.853 | 2.325–6.518 | 0.001 | < 0.001 | 4.104 | 2.395–6.718 | < 0.001 |
TRIM44 staining (Low vs. High) | 0.010 | 1.297 | 1.040–2.215 | 0.019 | 0.005 | 1.230 | 1.012–2.010 | 0.004 |