Table 1 Correlations between expression of TRIM47 protein and clinicopathological factors
From: TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4
Clinicopathological feature | Total 100 | Expression of TRIM47 | P value (χ2 test) | |
|---|---|---|---|---|
Low (n = 24,24%) | High (n = 76,76%) | |||
Age(years) | ||||
 < 65 | 48 | 10(41.7) | 38(50.0) | 0.476 |
 ≥65 | 52 | 14(58.3) | 38(50.0) | |
Gender | ||||
 Male | 67 | 18(75.0) | 49(64.5) | 0.339 |
 Female | 33 | 6(25.0) | 27(35.5) | |
Tumor location | ||||
 Rectum | 47 | 11(45.8) | 36(47.4) | 0.895 |
 Colon | 53 | 13(54.2) | 40(52.6) | |
Tumor size | ||||
 <30cm3 | 68 | 21(87.5) | 47(61.8) | 0.019 |
 ≥30 cm3 | 32 | 3(12.5) | 29(38.2) | |
Histological differentiation | ||||
 Well/moderate | 23 | 10(41.7) | 13(17.1) | 0.013 |
 Poor | 77 | 14(58.3) | 63(82.9) | |
T classification | ||||
 T1,2 | 21 | 9(37.5) | 12(15.8) | 0.023 |
 T3,4 | 79 | 15(62.5) | 64(84.2) | |
TNM stage(AJCC) | ||||
 Stage I, II | 43 | 6(25.0) | 37(48.7) | 0.041 |
 Stage III, IV | 57 | 18(75.0) | 39(51.3) | |
Invasive depth | ||||
 Mucous/muscular layer | 20 | 8(33.3) | 12(15.8) | 0.080 |
 Serosa | 80 | 16(66.7) | 64(84.2) | |
Lymph node metastasis | ||||
 Absent | 57 | 18(75.0) | 39(51.3) | 0.041 |
 Present | 43 | 6(25.0) | 37(48.7) | |
Distant metastasis | ||||
 Absent | 86 | 22(91.7) | 64(84.2) | 0.508 |
 Present | 14 | 2(8.3) | 12(15.8) | |
Vascular invasion | ||||
 Absent | 69 | 19(79.2) | 50(65.8) | 0.217 |
 Present | 31 | 5(20.8) | 26(34.2) | |