Fig. 6
From: Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression
Intercellular transfer of miR-3188 by exosomes inhibits tumor growth in vivo. a MiR-3188-overexpressed CAL27 cells were utilized to generate xenografts in nude mice. The graphics of xenografts, tumor growth curve and tumor weights showed that miR-3188 inhibited the xenograft tumor growth in nude mice. b NFs silenced miR-3188 were mixed with CAL27 to generate xenografts. Besides, GW4869 was intraperitoneal injected to block the transportation of endogenous miR-3188 via exosomes. The data showed that suppression of miR-3188 in NFs or inhibition of exosome secretion by GW4869 retarded the xenograft tumor growth. c Immunohistochemical analysis of BCL2 expression, Ki-67 staining and TUNEL assay in the xenografts (Scale bar: main = 50 μm; insert = 20 μm). (NC, negative control. ns, no significant difference, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)