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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Autophagy inhibition enhances PD-L1 expression in gastric cancer

Fig. 6

Immunohistochemical staining of PD-L1 and autophagy markers in human gastric cancers. a LC3 was found to be mainly expressed in the cytoplasm of gastric cancer cells. b p62/SQSTM1 staining was found in both the nucleus and cytoplasm. c p62/SQSTM1 and LC3 expression levels were dichotomized into high and low categories based upon total IHC expression score (4–9, high; 0–3, low). Missing data for p62/SQSTM1 (n = 8) and LC3 (n = 11). d PD-L1 protein was detected in patients with gastric cancer by IHC. Patients with ≥5% positive tumor cells or immune cells was considered to be PD-L1 positive. e The levels of PD-L1 expression were dichotomized into positive (≥ 5%) and negative categories (< 5%). f p62/SQSTM1 and LC3 expression levels were positively correlated with the levels of PD-L1 protein based upon total IHC expression score. Magnification, × 200, × 400, × 600

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