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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

Fig. 4

G0S2 regulates glioma cell DNA repair in response to radiation. a Representative images of γ-H2AX (p-S139- H2AX) staining of glioma GSC1123/shC, GSC1123/shG0S2–1 and GSC1123/shG0S2–2 cells at 8 h with or without with 10 Gy irradiation. Scale bars: 50 μm. b Quantitative γ-H2AX staining assays of A. Error bars, SD. *, p < 0.05. c WB analyses of effect of G0S2 knockdown on γ-H2AX expression in A. Data represent two independent experiments with similar results. d Overexpression of G0S2 inhibited DNA damage induced by radiation. Representative images of γ-H2AX staining of glioma LN229/shC, LN229/G0S2, U87/shC and U87/G0S2 cells at 8 h post-IR with 10 Gy. Scale bars: 50 μm. e Quantitative γ-H2AX staining assays of F. Error bars, SD. *, p < 0.05. f WB analysis of effects of G0S2-overexpression on γ-H2AX expression in D

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