Fig. 2

Linc00668 is a potential target of SNH. a. Heat map of the differential expression of screened lncRNA and mRNA sequences in NCI-H1299 cells treated or not treated with SNH for 24 H. b. Bioinformatics analysis of Linc00668 expression in human lung adenocarcinoma and lung squamous cell carcinoma tumour tissues compared with normal tissues. c. Association of Linc00668 expression with NSCLC patient disease-free survival and overall survival. d. Linc00668 expression in 5 NSCLC cell lines, 1 human bronchial epithelial cell line (HBE) and 1 human renal epithelial cell line (293 T) as determined by qRT-PCR. e. Linc00668 expression in SNH-treated A549 and NCI-H1299 cells as determined by qRT-PCR. f. Validation of Linc00668 overexpression by p-Linc00668 in A549 and NCI-H1299 cells as determined by qRT-PCR. g. Validation of sh-RNA knockdown efficiency in NCI-H1299 cells as determined by qRT-PCR. The bars and error bars indicate the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001