Table 1 Categories of TAs
From: Cancer DNA vaccines: current preclinical and clinical developments and future perspectives
TA category | TA subtype | Examples |
|---|---|---|
Mutational antigens | Products of mutated oncogenes (TSA) | P53, Ras, Bcr-Abl |
Neoantigens | Case-specific mutations | |
Tumor associated antigens (TAAs) | Products of silent genes | Cancer/testis antigens (a-fetoprotein, MAGE-1, NY-ESO1) |
Differentiation antigens | Gp100, tyrosinase, Melan-A, MART-1, TRP-1/− 2 | |
Universal tumor antigens | Her2/neu, telomerase, survivin | |
Oncoviral TAAs | HPV E6, E7, EBV-latent membrane proteins |