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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner

Fig. 8

Model of the GTSE1 mechanism in breast cancer. a GTSE1 and p21 were the target gene of p53, and GTSE1 could inhibit the function of p53. b In MCF7 cells with wild type homozygote of p53, GTSE1 played a role in a p53 dependent manner. c In MDA-MB-231 cells with mutant heterozygote of p53, GTSE1 played a role in a p53 partial dependent manner. d In MDA-MB-468 cells with mutant homozygote of p53, GTSE1 played a role in a p53 independent manner

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