Fig. 7
From: Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer
Spautin-1 suppresses PCa growth in vivo. a and b 22Rv1 and PC3 cells were engrafted into BALB/c nude mice and treated with Spautin-1 (20 mg/kg/d) for one month. Xenograft images are shown. c and d Tumor size was recorded weekly and summarized. e and f Tumor weight (left) and body weight (right) measured at the end of treatment are shown. ***p<0.05 versus vehicle control (CTR). g Immunohistochemistry staining assay was performed to detect the protein expression of Ki67 in the indicated xenograft samples. Representative images are shown. Scale bar = 50 μm. h TUNEL staining was performed to detect the apoptotic cells of xenografts. Representative images were shown. Scale bar = 50 μm