Skip to main content
Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Cisplatin resistant lung cancer cells promoted M2 polarization of tumor-associated macrophages via the Src/CD155/MIF functional pathway

Fig. 7

High expression of Src, MIF and CD155 is associated with poor survival in patients with NSCLC. a A public database of NSCLC patients was queried for Src, MIF and CD155 expression. Kaplan-Meier overall survival (KM) plots were drawn for each marker. The clinical samples were stratified into high and low expression of Src, MIF and CD155 respectively. In all three KM plots showed that the high expression of Src, MIF or CD155 predicts for a shorter overall survival rate in the patients. b Immunohistochemical analyses of 20 pairs clinical samples from our own hospital. The staining intensity score was compared between cisplatin sensitive and resistant samples. A higher staining score of Src, MIF and CD155 was observed in the resistant samples as compared to their cisplatin-sensitive counterparts. The lower panels depict the representative micrograph of samples stained with respective markers. P-value is indicated. c An increased CD163high and CX3CR1high M2 TAMs (by flow cytometry) were identified within the CDDP-resistant tumor samples as compared to CDDP-sensitive counterparts. d A negative correlation was found between the percentage of CD163high and CX3CR1high M2 TAMs and CDDP-sensitivity. The green lines delineate the connection between high percentage of CD163high and CX3CR1high M2 TAMs and their corresponding CDDP-sensitivity

Back to article page