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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF

Fig. 4

a Level of SNHG15 after overexpression in HCT116 cells determined by qRT-PCR (b) Change in proliferation ability of HCT116 cells after overexpression of SNHG15 in comparison with control. c Colony formation ability in overexpressing cells comparing to control cells. d SNHG15 RNA level after Transfection SW480 cells with SNHG15-vector via Empty vector. e Change in cell proliferation ability after SNHG15 overexpression in SW480 cell line. f Results of colony formation assay after overexpressing SNHG15 in SW480 cells. g Cell cycle analysis in HCT 116 cells after overexpression of SNHG15 using propidium iodide staining. h Percentage of apoptotic HCT 116 cells determined by annexin V and 7-AAD staining. i Invasion ability of HCT116 cells after overexpression of SNHG15. j Tumor formation in immunodeficient mice of the same cell lines (n = 7). P value is calculated by two-tailed Student’s t-test and graphs shows mean ± SEM of values (*p < 0.05, **p < 0.01, ***p < 0.001)

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