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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation

Fig. 3

Fn14 inhibits cisplatin resistance in HGSOC primary cancer cells with p53-R248Q. (a) and (b) CCK-8 assay was performed to detect cell viability in primary cells with p53 R248Q after infection with Fn14 lentivirus or control, *p < 0.05. Western blot analysis detecting the DNA damage maker in primary cells infected with Fn14 lentivirus. (c) and (d) Effects of Fn14 on apoptosis of primary cells were determined by flow cytometry analysis, **p < 0.01. (e) and (f) Western blot analysis detecting the activation of Caspase-3 and the expression of Bcl-2 in primary cells after infection with Fn14 lentivirus. Unpaired Student’s t test was performed for comparisons between two groups

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