Fig. 3

LINC01197 significantly inhibits PDAC cell proliferation and growth both in vitro and in vivo. a Clone formation assay showed that knockdown of LINC01197 dramatically increased HPNE clone numbers. b Clone formation ability of PDAC cell lines, AsPC1, BxPC3, and PANC1, was significantly decreased when LINC01197 was overexpressed. c Xenograft tumor formation assays showed that increased expression of LINC01197 inhibits subcutaneous tumor formation in PANC1 and BxPC3 cell lines. d IHC assays show that expression of Ki67 in PANC1 and BxPC3 stable cells induced tumor formation. P < 0.05 indicates a significant difference and all assays were performed in triplicate