Fig. 5

LINC01197 disrupts the interaction between β-catenin and TCF4. a Nuclear and cytoplasm β-catenin level as detected by western blotting in PANC1 and BxPC3 cells. b–c Co-IP assays showed that TCF4 binding to β-catenin is decreased in LINC01197-overexpressing PDAC cells (B) and significantly elevated in LINC01197-silenced HPNE cells (c, d) β-catenin absence attenuates HPNE colony formation caused by LINC01197 knockdown. P < 0.05 indicates a significant difference and all assays were performed in triplicate