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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer

Fig. 5

EIF4A inhibitor Silvestrol inhibits tumor growth, sphere formation and induces apoptosis when combined with oxaliplatin in CRC cells. a MTT assays showed Viability of the DLD1 and HCT116 cells treated with silvestrol of different concentrations. b Images (left) and quantification (right) of the indicated cells treated with silvestrol in colony formation assays. c Quantification of cell apoptosis of the indicated cells treated with silvestrol in Annexin-V/propidium iodide (PI) assays. d Representative images (left) and quantification (right) of sphere formation of the indicated cells treated with silvestrol. *, P < 0.05; **, P < 0.01 versus the control

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