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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Glioma stem cells-derived exosomal miR-26a promotes angiogenesis of microvessel endothelial cells in glioma

Fig. 8

Internalization of exosomes secreted from GSCs carrying miR-26a promotes angiogenesis of HBMECs through the inhibition of PTEN and activating the PI3K/Akt signaling pathway via elevation of VEGF. PI3K, phosphatidylinositol-3 kinases; miR-26a, microRNA-26a; NC, negative control; GSCs, glioma stem cells; PTEN, phosphatase and tensin homolog deleted on chromosome ten; Akt, protein kinase B; HBMECs, human brain microvascular endothelial cells; VEGF, vascular endothelial growth factor

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