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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells

Fig. 8

Downregulation of GMEB1 inhibited A549 xenograft tumor growth in vivo. a A549 cells stably overexpressing shGMEB1 RNA were seeded in 6-well plates and harvested after 24 h for western blot analysis. b A549 cells stably overexpressing shGMEB1 RNA were subcutaneously injected into the right side of the abdominal region of athymic nu/nu mice. Mice weights were measured using electronic balance every 2 days. c Tumor sizes were measured with calipers. The error bars represent the SD, ** P < 0.01, and *** P < 0.001. d Tumors were dissected and pictures taken. e Tumor weights were measured using electronic balance. The error bars represent the SD, ** P < 0.01, and *** P < 0.001

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