Fig. 9From: Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cellsRegulatory mechanism of CFLARL by GMEB1 and USP40. GMEB1 acts as an adaptor protein to improve the interaction of USP40 and CFLARL. USP40 targets CFLARL for de-ubiquitination to stabilize CFLARL protein levels. GMEB1 inhibits the activation of pro-caspase 8 via CFLARL and inhibits apoptosisBack to article page