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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells

Fig. 9

Regulatory mechanism of CFLARL by GMEB1 and USP40. GMEB1 acts as an adaptor protein to improve the interaction of USP40 and CFLARL. USP40 targets CFLARL for de-ubiquitination to stabilize CFLARL protein levels. GMEB1 inhibits the activation of pro-caspase 8 via CFLARL and inhibits apoptosis

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