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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis

Fig. 3

PD-1R mice exhibited decreased T cell accumulation and effector function. a Tcm and Tem cell populations in the LN and SP of the PD-1S (n = 16) and PD-1R (n = 7)groups were quantified. Representative flow cytometry plots show a decreased Tcm cell population in the PD-1R group. b, c, d Representative flow cytometric analysis and the percentages of CD4+ and CD8+ T cells expressing IL-2, IFN-γ, and TNF-α in the LN and SP of the PD-1 R and PD-1 S groups are shown. We found that the IL-2 and IFN-γ expression in the splenic CD4+ T cells and CD8+ T cells in the PD-1R group was significantly reduced compared to that in the PD-1S group. All data represent the mean ± SEM. Statistical significance was determined by Student’s t test, *P < 0.05, **P < 0.01, ***P < 0.001. LN, lymph node; SP, spleen

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