Fig. 1

MTMR2 is highly expressed in GC tissues and correlated with the clinicopathological features and the outcome of the patients. a Representative images of MTMR2 IHC staining in normal mucosa tissues, GC tissues and metastatic lymph node (scale bar = 50 μm). (Aa) Absence of MTMR2 expression in normal gastric mucosa. (Ab-e) The intensity of MTMR2 staining was increased with the tumor invasion depth (b: carcinoma in situ; c: submucosa; d: muscularis; d: serosa). (Af) Strong staining of MTMR2 was observed in metastatic lymph node. b The percentage of MTMR2^high in GC tissues was significantly higher than that in adjacent normal tissues; ** P < 0.01. c In six pairs of fresh surgical GC specimen, the expression level of MTMR2 protein detected by western blot in tumor tissues (T) was higher than that in adjacent normal tissues (N). d Data in the TCGA database showed higher MTMR2 expression in GC tumor tissues compared to adjacent normal tissues; * P < 0.05. e Analysis of GEO GSE 27342 showed a significantly higher MTMR2 expression in GC tissues compared to adjacent normal tissues. f, g Kaplan-Meier analysis of 295 GC patients indicated that high MTMR2 expression was associated with shorter overall survival (OS) (f) and disease free survival (DFS) time (g). h, i Kaplan-Meier analysis of GC patients from dataset 203212_s_at in Kaplan-Meier plotter indicated shorter OS (h) and DFS time (i) for patients with MTMR2^high