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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer

Fig. 4

EET metabolite levels are correlated with the invasion and migration ability of basal B mesenchymal-like TNBC cells. Validation and comparison of a CPYP2C19 gene expression, b total EET concentrations and c invasion and migration potential among shCYP2C19 and shCYP4A2 knockdown and 17-ODYA-, HET0016- and AUDA-treated human-derived TNBC cells. Expression levels of metastasis-related proteins were significantly affected in CYP2C19-depleted or CYP-inhibitor treated d basal B TNBC cells (MDA-MB-231) but not in e basal A TNBC cells (HCC1937). All analyses include 3 biological replicates and 4 technical replicates. Error bars indicate mean ± SEM. Significantly different values (P = 0.05, ANOVA) are denoted by letters. All analyses include 3 biological replicates and 4 technical replicates. Error bars indicate mean ± SEM. Significantly different values (P = 0.05, ANOVA) are denoted by letters. Capitalized letters in c are for the migration data comparison and analysis. Representative blots of three independent experiments are shown

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