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Fig. 10 | Journal of Experimental & Clinical Cancer Research

Fig. 10

From: Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma

Fig. 10

AGAP2-AS1 mediates the promoting effects of hypoxia on metastasis and EMT of HCC cells. a The expressions of HIF-1α in different time points in normoxia and hypoxia condition. b The levels of AGAP2-AS1 in Hep3B cells cultured in normoxia and hypoxia. c Transwell assays revealed that hypoxia promoted migration and invasion of Hep3B cells, while AGAP2-AS1 knockdown abolished the effects of hypoxia. d Hypoxia facilitated the EMT process of Hep3B cells and AGAP2-AS1 knockdown showed an opposite effect. *P < 0.05

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