Fig. 9

AKT phosphorylation is essential for the biological function of ANXA11 in HCC. a HCCLM3 and Hep3B cells that were transfected with corresponding ANXA11 vectors were subjected to immunoblotting for phosphorylated AKT and AKT. AKT inhibitor MK2206, or AKT phosphorylation activator IGF-1, abolished the cell proliferation (b), migration (c), invasion (d), apoptosis (e) and EMT process (f) of HCC cells which were transduced of ANXA11 vectors. *P < 0.05