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Table 1 Correlation between the clinicopathologic characteristics and lncRNA AGAP2-AS1 and miR-16-5p expression in HCC (n = 137)

From: Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma

Clinical parameters Cases Expression level P value Expression level   P value
AGAP2-AS1high
(n = 69)
AGAP2-AS1low
(n = 68)
miR-16-5phigh
(n = 66)
miR-16-5plow
(n = 71)
Age(years)
  < 65 years 76 40 36 0.554 35 41 0.579
  ≥ 65 years 61 29 32   31 30  
Gender
 Male 109 55 54 0.965 53 56 0.836
 Female 28 14 14   13 15  
Tumor size (cm)
 <5 cm 108 48 60 0.007* 59 49 0.004*
 ≥ 5 cm 29 21 8   7 22  
Tumor number
 solitary 119 59 60 0.637 57 62 0.868
 multiple 18 10 8   9 9  
Edmondson
 I + II 98 41 57 0.002* 50 48 0.291
 III + IV 39 28 11   16 23  
TNM stage
 I + II 110 50 60 0.020* 58 52 0.031*
 III + IV 27 19 8   8 19  
Capsular
 Present 93 47 46 0.953 46 47 0.661
 Absent 44 22 22   20 24  
Venous invasion
 Present 18 14 4 0.013* 3 15 0.004*
 Absent 119 55 64   63 56  
AFP
 <400 ng/ml 36 21 15 0.265 17 19 0.894
 ≥ 400 ng/ml 101 48 53   49 52  
HBsAg
 positive 123 61 62 0.592 59 64 0.885
 negative 14 8 6   7 7  
  1. HCC hepatocellular carcinoma, AFP alpha-fetoprotein, TNM tumor-node-metastasis
  2. *Statistically significant is in bold