Skip to main content

Table 2 Overview of clinical studies on the effect of STF on the toxicity of chemotherapy

From: Effects of short-term fasting on cancer treatment

Authors, site Human Subjects Treatment Outcome
Safdie et al. 2009, USC, USA [136] 10 human subjects with distinct malignancies Distinct, + STF varying from 48 to 140 h prior and 5–56 h after CT Safe and feasible.
Reduction in CT-induced side effects.
Badar et al. 2014, KFMC, Saudi Arabia, NCT00757094 [135] 11 human subjects with distinct malignancies IF during Ramadan when receiving CT Safe and feasible.
Reduction in CT-induced side effectsa.
Dorff et al. 2016, USC, USA, NCT00936364, [22, 137] 20 human subjects with distinct malignancies Platinum based CT + 24 h, 48 h or 72 h STF Safe and feasible .
Reduces DNA damage in leukocytes (dose response).
Reduction of IGF-1 (dose response).
de Groot et al. 2015, LUMC, The Netherlands NCT01304251 [131] 13 women with stage II and III HER2 negative breast cancer TAC CT ± 48 h STF Safe and feasible.
Reduction in IGF-1
Beneficial effect on erythrocytes and thrombocytes
Possible reduction in DNA damage in healthy cells
Bauersfeld et al. 2018, Charite University, Germany, NCT01954836 [138] 34 women with breast and ovarian cancer CT ± 60 h STF (cross-over) Safe and feasible
Beneficial effect on QOL, fatigue and well-being
  1. USC University of Southern California, KFMC King Fahad Medical City, LUMC Leiden University Medical Center, UC Davis University of California, Davis School of Veterinary Medicine, STF Short-term fasting, IF intermittent fasting, CT Chemotherapy, TAC docetaxel/doxorubicin/cyclophosphamide, IGF-1 insulin-like growth factor-1, QOL Quality of life  ano statistics performed