Fig. 3

miR-let-7b and miR-let-7c inhibited mucosal melanoma cells in vitro migration, invasion and in vivo metastasis. miR-let-7b and miR-let-7c inhibited the migration and invasion of HMVII (a) and GAK (b) in vitro; statistical analyses are in (c and d). The results are presented as the means ± standard deviations from triplicate experiments and statistically analysed by Mann-Whitney U test. *P < 0.05. miR-let-7b and miR-let-7c inhibited liver (e) and lung (f) metastasis of HMVII. g Representative images of HE staining of liver and lung metastatic sections. h The number of metastatic foci in lung tissues is presented as the means ± standard deviations from triplicate counts