Fig. 4

miR-let-7b and miR-let-7c induced mucosal melanoma cell apoptosis and cell cycle arrest at G1 phase. miR-let-7b and miR-let-7c induced late and total apoptosis of HMVII (a) cells; statistical analyses are in (c). miR-let-7b induced late and total apoptosis of GAK cells (b); statistical analyses are in (d). miR-let-7b and miR-let-7c induced apoptosis and cell cycle arrest at G1 phase of HMVII (e) and GAK (f) cells; analyses are in (g and h). The results are presented as the means ± standard deviations from triplicate experiments and statistically analysed by Mann-Whitney U test. *P < 0.05