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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy

Fig. 7

miR-let-7b and miR-let-7c increased the sensitivity to temozolomide and paclitaxel in mucosal melanoma. a miR-let-7b and miR-let-7c prolonged PFS with temozolomide-based and paclitaxel-based chemotherapy in mucosal melanoma patients. Data were calculated using Kaplan-Meier analysis. Representative images for PDX models of tumour volume (b) and HE staining (c) treated with TMZ and PTX. The tumour growth inhibition (TGI) was significantly higher in PDX1 than in PDX2 (P < 0.001 for treatment of TMZ and P = 0.044 for treatment of PTX) (d and e). Each subgroup contained 3 mice. The results are presented as the means ± standard deviations and statistically analysed by repeated measures analysis of variance. f miR-let-7b and miR-let-7c could increase sensitivity of TMZ and PTX treatment in GAK. g MTDH reversed sensitivity to PTX for miR-let-7b and miR-let-7c in vitro. The cell viability was detected 48 h after treatment in different concentrations of chemotherapeutic agents using the Cell Titer-Glo luminescent cell viability assay. The results are presented as the means ± standard deviations from six replicates and statistically analyzed by Mann-Whitney U test. *P < 0.05

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