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Table 3 Upregulated genes in mucosal melanoma tissues were predicted by prediction software packages as potential target genes

From: miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy

Genes

Fold change

TargetScan

miRanda

DIANA-microT

MTDH

4.01

Include

Include

Include

CALU

3.32

Include

Include

Include

SULF1

5.02

Include

Exclude

Include

FBXO32

8.03

Exclude

Exclude

Include

BZW2

3.99

Exclude

Include

Exclude

ABL2

2.15

Exclude

Exclude

Include

PLD3

4.11

Exclude

Include

Exclude

MLXIP

2.05

Exclude

Include

Exclude

CERS2

2.45

Exclude

Exclude

Exclude

  1. Include: Prediction software package included the gene as a target of miR-let-7b and miR-let-7c. Exclude: Prediction software package excluded the gene as a target of miR-let-7b and miR-let-7c. Fold change: the mRNA expression level compared with negative control. Nine genes were upregulated among mucosal melanoma. Among the prediction software packages: miRNA, TargetScan, and DIANA-microT, 2 genes were predicted as targets of miR-let-7b and miR-let-7c with higher probability of preferential conservation. Although SULF1 was predicted as a target gene by TargetScan, its site had lower probability of preferential conservation