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Table 3 Upregulated genes in mucosal melanoma tissues were predicted by prediction software packages as potential target genes

From: miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy

Genes Fold change TargetScan miRanda DIANA-microT
MTDH 4.01 Include Include Include
CALU 3.32 Include Include Include
SULF1 5.02 Include Exclude Include
FBXO32 8.03 Exclude Exclude Include
BZW2 3.99 Exclude Include Exclude
ABL2 2.15 Exclude Exclude Include
PLD3 4.11 Exclude Include Exclude
MLXIP 2.05 Exclude Include Exclude
CERS2 2.45 Exclude Exclude Exclude
  1. Include: Prediction software package included the gene as a target of miR-let-7b and miR-let-7c. Exclude: Prediction software package excluded the gene as a target of miR-let-7b and miR-let-7c. Fold change: the mRNA expression level compared with negative control. Nine genes were upregulated among mucosal melanoma. Among the prediction software packages: miRNA, TargetScan, and DIANA-microT, 2 genes were predicted as targets of miR-let-7b and miR-let-7c with higher probability of preferential conservation. Although SULF1 was predicted as a target gene by TargetScan, its site had lower probability of preferential conservation