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Table 4 Comparison of TMB status in ADC and SQCC study groups

From: PD-L1 expression and tumor mutational burden status for prediction of response to chemotherapy and targeted therapy in non-small cell lung cancer

Characteristic ADC P value SQCC P value
High (n, %) Low/Moderate (n, %) High (n, %) Low/Moderate (n, %)
Age (years) 0.805   1
 <58 (< 60) # 9 14% 55 86%   7 29% 17 71%  
 ≥58 (≥60) 9 13% 63 87% 7 26% 20 74%
Sex 0.068   0.704
 Male 15 17% 71 83%   12 30% 28 70%  
 Female 3 6% 47 94% 2 18% 9 82%
Smoking status 1   0.512
 Never smoker 15 14% 94 86%   11 31% 25 69%  
 Smoker 3 11% 24 89% 3 20% 12 80%
Pathologic stage 0.796   0.529
 IIIB 8 15% 46 85%   7 33% 14 67%  
 IV 10 12% 72 88% 7 23% 23 77%
Mutation status 0.049      \
 EGFR mutant 4 7% 54 93%   0 0% 2 100%  
 KRAS mutant 5 29% 12 71% 2 100% 0 0%
Other 9 15% 52 85% 12 26% 35 74%
PD-L1 in TC
 Strong+ 7 26% 20 74% 0.051 8 57% 6 43% 0.01
 Moderate/strong+ 8 22% 28 78% 0.084 10 48% 11 52% 0.01
 Any+ 9 18% 41 82% 0.293 11 39% 17 61% 0.058
 Negative 9 10% 77 90%   3 13% 20 87%  
PD-L1 in IC
 Strong+ 6 22% 21 78% 0.199 1 8% 11 92% 0.141
 Moderate/strong+ 6 18% 28 82% 0.389 1 7% 13 93% 0.076
 Any+ 8 17% 40 83% 0.431 7 24% 22 76% 0.752
 Negative 10 11% 78 89%   7 32% 15 68%  
  1. Note: #: for age of SQCC