Fig. 5

Long non-coding RNA TPTEP1 inhibits STAT3 transcriptional activity. a The luciferase activity of STAT3 response element was detected by Luciferase assays in TPTEP1-knockdowned or TPTEP1-overexpressed QGY-7703 cells. b The mRNA (left panel) and protein (right panel) expression levels of MCL1, cyclinD1, Bcl-xl and IL6 were detected by qRT-PCR assays or western blotting in TPTEP1-knockdowned or TPTEP1-overexpressed QGY-7703 cells. c and d Cell proliferation c and invasive ability d were detected by MTT assays or transwell invasion assays in QGY-7703 cells infected with the lentivirus expressing full-length TPTEP1, the deletion fragments, or the control. Data are represented as means ± SD (n = 3; ^*represents P < 0.05)