Fig. 7

Long non-coding RNA TPTEP1 inhibits tumor masses in mouse and is frequently downregulated in HCC tissues. a TPTEP1 overexpression significantly inhibits tumor masses in vivo in a subcutaneous xenograft mouse model of HCC. Left, representative images of xenograft tumors from the nude mice. Middle, expression analysis of p-STAT3 in tumor tissues of each group by immunochemistry (× 200 magnification). Right, expression analysis of TPTEP1 in tumor tissues of each group by in situ hybridization (× 200 magnification). b Comparison of tumor weights from each group of nude mice. c Number of liver and lung metastatic foci in each group. d The copy numbers of TPTEP1 were determined in 32 pairs of HCC tissues and adjacent normal tissues using qRT-PCR. e Fold change of TPTEP1 copy number variations in 32 paired tissues. Data are represented as means ± SD (^*represents P < 0.05)