Fig. 6From: Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanismCelecoxib inhibits PGE2 production and M2-like polarizing ability of senescent thyrocytes and BCPAP thyroid cells. PGE2 secretion, determined by ELISA, of senescent thyrocytes (STh) and BCPAP cells treated with celecoxib at the indicated doses (a). Macrophages induced by CM from samples in (a) were analyzed for CD206 and CD163 expression by FACS (b, c) and for the secretion of CCL17 by ELISA (d). Statistical significance was determined by unpaired t test. *p < 0.05, **p < 0.01, ***p < 0.001Back to article page