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Table 3 Synergism between BTK and EGFR inhibitors

From: p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

 

Ibrutinib

AVL-292

RN486

 

Gefitinib

Erlotinib

Gefitinib

Erlotinib

Gefitinib

Erlotinib

Calu-6

0.04

0.20

0.18

0.18

0.13

0.10

SK-Lu-1

0.02

0.20

0.13

0.17

0.11

0.11

NCI-H1975

0.01

0.01

0.74

0.26

0.34

0.17

NCI-H2228

0.01

ant

ant

ant

0.18

0.11

  1. Combination Index (CI) was calculated as reported by Fransson (Fransson, A., et al. (2016) J Ovarian Res 9 [1]: 27) and detailed in material and methods
  2. 0.8 < CI < 1.2 = additive effect, CI < 0.8 = synergistic effect (CI < 0.5 = strong synergistic effect), CI > 1.2 = sub-additive effect, ant = antagonistic effect