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Table 4 Synergism between BTK inhibitors and Chemoterapy

From: p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

 

Ibrutinib

AVL-292

RN486

 

CisPt

Pemetr

Gemcitab

CisPt

Pemetr

Gemcitab

CisPt

Pemetr

Gemcitab

Calu-6

0.11

ant

ant

0.3

0.23

0.28

0.04

0.05

0.01

SK-Lu-1

0.09

ant

ant

0.28

0.21

0.25

0.07

0.05

0.07

NCI-H1975

0.16

0.38

0.33

ant

0.51

0.52

0.08

0.05

0.02

NCI-H2228

0.22

0.41

0.41

0.47

0.43

0.47

0.06

0.06

0.03

  1. Combination Index (CI) was calculated as reported by Fransson (Fransson, A., et al. (2016) J Ovarian Res 9 [1]: 27) and detailed in material and methods
  2. 0.8 < CI < 1.2 = additive effect, CI < 0.8 = synergistic effect (CI < 0.5 = strong synergistic effect), CI > 1.2 = sub-additive effect, ant = antagonistic effect