Fig. 4From: Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cellsZNF143 was upregulated and functioned as an oncogene in glioma cells. a. ZNF143 was overexpressed in glioma tissues. Data are presented as the mean ± SD (n = 6, NBTs; n = 18, Low-grade glioma tissues; n = 25, High-grade glioma tissues). **P < 0.01 vs. Normal brain tissues. ##P < 0.01 vs. Low-grade glioma tissues. b. The ZNF143 expression was upregulated in glioma cells. Data are presented as the mean ± SD (n = 5, each group). **P < 0.01 vs. NHA. c-e. CCK-8 assay, flow cytometry analysis and migration and invasion assays were applied to measure the biological behaviors of glioma cells treated with ZNF143 overexpression or knockdown. Data represented mean ± SD (n = 5, each group). **P < 0.01 vs. ZNF143 (+)-NC group (negative control); ##P < 0.01 vs. ZNF143 (−)-NC group (negative control). Scale bar of migration and invasion assays represent 40 μmBack to article page