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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells

Fig. 4

ZNF143 was upregulated and functioned as an oncogene in glioma cells. a. ZNF143 was overexpressed in glioma tissues. Data are presented as the mean ± SD (n = 6, NBTs; n = 18, Low-grade glioma tissues; n = 25, High-grade glioma tissues). **P < 0.01 vs. Normal brain tissues. ##P < 0.01 vs. Low-grade glioma tissues. b. The ZNF143 expression was upregulated in glioma cells. Data are presented as the mean ± SD (n = 5, each group). **P < 0.01 vs. NHA. c-e. CCK-8 assay, flow cytometry analysis and migration and invasion assays were applied to measure the biological behaviors of glioma cells treated with ZNF143 overexpression or knockdown. Data represented mean ± SD (n = 5, each group). **P < 0.01 vs. ZNF143 (+)-NC group (negative control); ##P < 0.01 vs. ZNF143 (−)-NC group (negative control). Scale bar of migration and invasion assays represent 40 μm

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