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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells

Fig. 6

ASAP3 and MYB were downstream targets of ZNF143, moreover, FAM224A expression was activated by ZNF143. a. The expression levels of ASAP3 were upregulated in glioma tissues (left) and cells (right). Left: Data are presented as the mean ± SD (n = 6, NBTs; n = 18, Low-grade glioma tissues; n = 25, High-grade glioma tissues). **P < 0.01 vs. Normal brain tissues. ##P < 0.01 vs. Low-grade glioma tissues. Right: Data are presented as the mean ± SD (n = 5, each group). **P < 0.01 vs. NHA. b-c. Weastern blot assay showed that the expression of ASAP3 and MYB were regulated by miR-590-3p and ZNF143. d-e. ChIP assay demonstrated that ZNF143 could promote ASAP3 and MYB expression by binding to their promoters in glioma cells. f-g. qRT-PCR and ChIP assays confirmed that ZNF143 could directly activate the promoter of FAM224A and upregulated its expression in glioma cells

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