Table 1 Association of FOXM1 and KIF4A expression levels with different clinicopathologic characteristics in HCC
From: FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression
Clinicopathologic | FOXM1 expression | KIF4A expression | ||||
|---|---|---|---|---|---|---|
Low | High | p value | Low | High | p value | |
Count (n%) | Count (n%) | Count (n%) | Count (n%) | |||
Sex | ||||||
 Male | 89 (82.4) | 89 (86.4) | 0.424 | 92 (80.7) | 86 (88.7) | 0.113 |
 Female | 19 (17.6) | 14 (13.6) | 22 (19.3) | 11 (11.3) | ||
Age, years | ||||||
  ≤ 50 | 53 (49.1) | 50 (48.5) | 0.939 | 53 (46.5) | 50 (51.5) | 0.464 |
 >50 | 55 (50.9) | 53 (51.5) | 61 (53.5) | 47 (48.5) | ||
AFP Level, ug/L | ||||||
  ≤ 20 | 35 (32.4) | 26 (25.2) | 0.393 | 39 (34.2) | 22 (22.7) | 0.148 |
 >20 | 67 (62.0) | 73 (70.9) | 69 (60.5) | 71 (73.2) | ||
 untested | 6 (5.6) | 4 (3.9) | 6 (5.3) | 4 (4.1) | ||
CA-199, U/mL | ||||||
  ≤ 27 | 69 (63.9) | 69 (67.0) | 0.177 | 72 (63.2) | 66 (68.0) | 0.393 |
 >27 | 17 (15.7) | 22 (21.3) | 20 (17.5) | 19 (19.6) | ||
 untested | 22 (20.4) | 12 (11.7) | 22 (19.3) | 12 (12.4) | ||
ALB, g/L | ||||||
 <34 | 90 (83.3) | 87 (84.5) | 0.823 | 96 (84.2) | 81 (83.5) | 0.890 |
  ≥ 34 | 18 (16.7) | 16 (15.5) | 18 (15.8) | 16 (16.5) | ||
Pre-S1 | ||||||
 Negative | 17 (15.7) | 11 (10.7) | 0.446 | 17 (14.9) | 11 (11.3) | 0.516 |
 Positive | 38 (35.2) | 34 (33.0) | 41 (36.0) | 31 (32.0) | ||
 Unknown | 53 (49.1) | 58 (56.3) | 56 (49.1) | 55 (56.7) | ||
TBIL, umol/L | ||||||
  ≤ 20.5 | 98 (90.7) | 90 (87.4) | 0.433 | 104 (91.2) | 84 (85.6) | 0.282 |
 >20.5 | 10 (9.3) | 13 (12.6) | 10 (8.8) | 13 (13.4) | ||
Cirrhosis | ||||||
 No | 42 (38.9) | 50 (48.5) | 0.157 | 46 (40.4) | 46 (47.4) | 0.302 |
 Yes | 66 (61.1) | 53 (51.5) | 68 (59.6) | 51 (52.6) | ||
HBV infection | ||||||
 Negative | 11 (10.2) | 8 (7.8) | 0.540 | 11 (9.6) | 8 (8.2) | 0.723 |
 Positive | 97 (89.8) | 95 (92.2) | 103 (90.4) | 89 (91.8) | ||
Histologic grade | ||||||
 Well | 14 (13.0) | 3 (2.9) | 0.003 | 15 (13.1) | 2 (2.0) | 0.001 |
 Moderate | 81 (75.0) | 74 (71.9) | 85 (74.6) | 70 (72.2) | ||
 Poor | 13 (12.0) | 26 (25.2) | 14 (12.3) | 25 (25.8) | ||
Vascular invasion | ||||||
 Negative | 89 (82.4) | 86 (83.5) | 0.834 | 100 (87.7) | 75 (77.3) | 0.045 |
 Positive | 19 (17.6) | 17 (16.5) | 14 (12.3) | 22 (22.7) | ||
TNM stage | ||||||
 StageI-II | 65 (60.2) | 31 (30.1) | 1.15 × 10 –5 | 70 (61.4) | 26 (26.8) | 4.91 × 10 –7 |
 StageIII-IV | 43 (39.8) | 72 (69.9) | 44 (38.6) | 71 (73.2) | ||