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Table 1 Association of FOXM1 and KIF4A expression levels with different clinicopathologic characteristics in HCC

From: FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression

Clinicopathologic FOXM1 expression KIF4A expression
Low High p value Low High p value
Count (n%) Count (n%) Count (n%) Count (n%)
Sex
 Male 89 (82.4) 89 (86.4) 0.424 92 (80.7) 86 (88.7) 0.113
 Female 19 (17.6) 14 (13.6) 22 (19.3) 11 (11.3)
Age, years
  ≤ 50 53 (49.1) 50 (48.5) 0.939 53 (46.5) 50 (51.5) 0.464
 >50 55 (50.9) 53 (51.5) 61 (53.5) 47 (48.5)
AFP Level, ug/L
  ≤ 20 35 (32.4) 26 (25.2) 0.393 39 (34.2) 22 (22.7) 0.148
 >20 67 (62.0) 73 (70.9) 69 (60.5) 71 (73.2)
 untested 6 (5.6) 4 (3.9) 6 (5.3) 4 (4.1)
CA-199, U/mL
  ≤ 27 69 (63.9) 69 (67.0) 0.177 72 (63.2) 66 (68.0) 0.393
 >27 17 (15.7) 22 (21.3) 20 (17.5) 19 (19.6)
 untested 22 (20.4) 12 (11.7) 22 (19.3) 12 (12.4)
ALB, g/L
 <34 90 (83.3) 87 (84.5) 0.823 96 (84.2) 81 (83.5) 0.890
  ≥ 34 18 (16.7) 16 (15.5) 18 (15.8) 16 (16.5)
Pre-S1
 Negative 17 (15.7) 11 (10.7) 0.446 17 (14.9) 11 (11.3) 0.516
 Positive 38 (35.2) 34 (33.0) 41 (36.0) 31 (32.0)
 Unknown 53 (49.1) 58 (56.3) 56 (49.1) 55 (56.7)
TBIL, umol/L
  ≤ 20.5 98 (90.7) 90 (87.4) 0.433 104 (91.2) 84 (85.6) 0.282
 >20.5 10 (9.3) 13 (12.6) 10 (8.8) 13 (13.4)
Cirrhosis
 No 42 (38.9) 50 (48.5) 0.157 46 (40.4) 46 (47.4) 0.302
 Yes 66 (61.1) 53 (51.5) 68 (59.6) 51 (52.6)
HBV infection
 Negative 11 (10.2) 8 (7.8) 0.540 11 (9.6) 8 (8.2) 0.723
 Positive 97 (89.8) 95 (92.2) 103 (90.4) 89 (91.8)
Histologic grade
 Well 14 (13.0) 3 (2.9) 0.003 15 (13.1) 2 (2.0) 0.001
 Moderate 81 (75.0) 74 (71.9) 85 (74.6) 70 (72.2)
 Poor 13 (12.0) 26 (25.2) 14 (12.3) 25 (25.8)
Vascular invasion
 Negative 89 (82.4) 86 (83.5) 0.834 100 (87.7) 75 (77.3) 0.045
 Positive 19 (17.6) 17 (16.5) 14 (12.3) 22 (22.7)
TNM stage
 StageI-II 65 (60.2) 31 (30.1) 1.15 × 10 –5 70 (61.4) 26 (26.8) 4.91 × 10 –7
 StageIII-IV 43 (39.8) 72 (69.9) 44 (38.6) 71 (73.2)
  1. AFP alpha fetoprotein, ALB serum albumin, TBIL total bilirubin, HBV hepatitis B virus, TNM tumor-node-metastasis
  2. p values were calculated by comparing the expression of FOXM1 and KIF4A with different clinical variables respectively using a chi-square test. p < 0.05 was considered statistically significant