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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

Fig. 4

Effect of VRK1 depletion on the formation of γH2AX and 53BP1 foci induced by olaparib, IR or their combination in A549 cells. a. Effect of si-Control on A549 cells treated with different doses of olaparib, IR or their combination on the formation of γH2AX foci. b. Effect of si-VRK1 on A549 cells treated with different doses of olaparib, IR or their combination on the formation of 53BP1 foci. c. Detection of VRK1 depletion in immunoblot. siC: siControl, siV: siVRK1–02. ns: not significant, ** p < 0.01, *** p < 0.001

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