Fig. 1

Principal Component Analysis (PCA) of RPPA data. The subset of antibodies selected after thresholding the correlation indices between different time points, was used for PCA on the correlation matrix of data at a single time point (8 h). The bi-plot in (a) shows the scores of analyzed samples, i.e. cell lines and SI113 levels, annotated by the color and the size of the symbols, respectively. The relative weight of individual endpoints (loadings) is overlaid and highlighted by arrows. Histograms in (b) and (c) show the relative contribution of endpoints (expressed as percentage of the contribution of all variables) with significantly high correlations in the first and the second PC, respectively. The red, dashed line indicates the threshold level of relative contribution