Fig. 3
From: Molecular pattern of lncRNAs in hepatocellular carcinoma
HCC-associated lncRNAs in transcription factors regulation. a Upper panel: lncSox4 recruits STAT3 to Sox4 promoter region to activate Sox4 transcription. Lower panel: decreased lncSox4 impairs STAT3-mediated Sox4 expression (b) Upper panel: lncHUR1 inhibits transcription of p21 and BAX by sequestering p53. Lower panel: decreased lncHUR1 releases p53 to bind to promoters of p21 and BAX, which activates transcription of them. c Upper panel: lnc-DILC inhibits NF-κB-mediated IL-6 transcription by blocking IL-6 promoter. Lower panel:NF-κB can bind to IL-6 promoter and promotes IL-6 transcription when lnc-DILC is decreased