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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Molecular pattern of lncRNAs in hepatocellular carcinoma

Fig. 3

HCC-associated lncRNAs in transcription factors regulation. a Upper panel: lncSox4 recruits STAT3 to Sox4 promoter region to activate Sox4 transcription. Lower panel: decreased lncSox4 impairs STAT3-mediated Sox4 expression (b) Upper panel: lncHUR1 inhibits transcription of p21 and BAX by sequestering p53. Lower panel: decreased lncHUR1 releases p53 to bind to promoters of p21 and BAX, which activates transcription of them. c Upper panel: lnc-DILC inhibits NF-κB-mediated IL-6 transcription by blocking IL-6 promoter. Lower panel:NF-κB can bind to IL-6 promoter and promotes IL-6 transcription when lnc-DILC is decreased

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