Fig. 4

HCC-associated lncRNAs in mRNA post-transcriptional regulation. a Left panel: PXN-AS1-L can sequester miR-24 with its exon4, thereby increasing PXN mRNA stability. Right panel: PXN-AS1-S does not consist of exon4, which releases miR-24 to bind to PXN mRNA 3’UTR. b Left panel: HULC can increase CLOCK mRNA stability by binding to its 5’UTR. Right panel: decreased HULC expression impairs CLOCK expression. c Left panel: lncRNA-ATB can increase ZEB1/2 mRNA stability by sequestering miR-200 s. Also, lncRNA-ATB can increase IL-11 mRNA stability by binding with it. Right panel: decreased lncRNA-ATB expression impairs ZEB1/2 and IL-11 expression. d Left panel: HuR can stabilize β-catenin by binding to its 3’UTR. Right panel: MIR22HG can down-regulate β-catenin mRNA by sequestering β-catenin mRNA