Fig. 6

HCC-associated lncRNAs in protein modification. a Left panel: TSLNC8 disrupts TKT-mediated STAT phosphorylation by sequestering STAT3 or TKT, which induces Ser727 phosphorylation and Tyr705 dephosphorylation in STAT3. Right panel: decreased TSLNC8 promotes the interaction between STAT3 and TKT, which induces TKT-mediated Ser727 dephosphorylation and Tyr705 phosphorylation in STAT3. b Left panel: HULC promotes ERK mediated YB-1 phosphorylation by acting as scaffold to bridge ERK and YB-1. Right panel: decreased HULC impairs ERK mediated YB-1 phosphorylation. c Left panel: lnc-β-Catm promotes ERK mediated β-catenin methylation by acting as scaffold to bridge EZH2 and β-catenin. Right panel: decreased lnc-β-Catm impairs EZH2 mediated β-catenin methylation