Fig. 7
From: Aberrant activation of CYR61 enhancers in colorectal cancer development
Schematic representation of enhancer regulation of CYR61 expression. Under normal conditions, CYR61 mRNA is transcribed at a low level. In colon cancer, FOXA1 and CBP mediate aberrant promoter-enhancer looping and help to establish the active chromatin state, which leads to an increase of CYR61 transcription