Fig. 6
Expression pattern and clinical value of GPAA1 in human gastric cancer. a Representative IHC staining for GPAA1 from the Ren Ji cohort, which contained 587 GC patients. The expression level was scored as -, +, ++, or +++ (Scale bars: 200 μm and 40 μm). b Percentage of specimens with different expression levels of GPAA1 according to clinical stage and pathological stage (569 patients with collected prognostic information were enrolled). c Representative IHC staining of ERBB2 from the Ren Ji cohort, which contained 587 GC patients. d Percentage of specimens with different expression levels of ERBB2 according to clinical stage and pathological stage (569 patients). e Correlation between GPAA1 and ERBB2 expression in the Ren Ji cohort (587 patients, Chi-square: P < 0.0001, log odds ratio: 4.794 (2.964–7.755), P < 0.0001). f Kaplan-Meier curve for the prognosis of patients with high and low levels of GPAA1 or ERBB2 expression in the Ren Ji cohort (569 patients). The study involved patients who had received gastrectomy from January 2006 to December 2011, and the final follow-up date was December 31, 2017. g Multivariate Cox regression analysis of the Ren Ji cohort (569 patients). *P < 0.05, **P < 0.01, ***P < 0.001