Fig. 6

Hypo-MSC activates YAP via EP4. a-b The mRNA levels of EP1-EP4 in 7402 and Hep3b under indicated conditions. c Protein levels of EP4 and CREB in indicated cells. d-e Protein and mRNA levels of YAP and its target genes in cells treated with CAY10598 (EP4 agonist) in indicated dose. f Quantification of Edu positive cells in EP4 knockdown cells via siRNA under different condition (n = 3). g-h Protein and mRNA levels of YAP and its target genes in EP4 knockdown cells via siRNA under indicated conditions. (*p < 0.05, **p < 0.01)