Fig. 7

Hypo-MSC promotes lipogenesis via EP4 mediated YAP activation in cells. a Cellular levels of TG in EP4 knockdown cells under indicated conditions (n = 3). b Protein levels of AKT, mTOR and SREBP1 in EP4 knockdown cells under indicated conditions. c The mRNA levels of lipogenic enzymes in EP4 knockdown cells under indicated conditions (n = 3). d The content of neutral lipids in EP4 knockdown cells under indicated conditions. e Proposed model for hypo-MSC on HCC progression. (*p < 0.05, **p < 0.01)