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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells

Fig. 6

The leukemogenic capacity of bcr-abl in mice was impaired by RFNs. a WBC counts in each group were counted. The maximum value of each mouse was recorded. b, c The weights of spleen and liver of mice in each group were measured. d The amount of human CD45+ cells was tested by flow cytometry. e The expression of BCR-ABL protein in each group was detected by immunofluorescent assay. f Immature cells from bone marrow were checked by Wright’s stain and the infiltration of spleen and liver was analyzed by H&E stain. g Kaplan-Meier method to analyze the survival curves of mice in each group

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